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http://dspace2020.uniten.edu.my:8080/handle/123456789/9726Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Bukhari, S.N.A. | |
| dc.contributor.author | Lauro, G. | |
| dc.contributor.author | Jantan, I. | |
| dc.contributor.author | Chee, C.F. | |
| dc.contributor.author | Amjad, M.W. | |
| dc.contributor.author | Bifulco, G. | |
| dc.contributor.author | Sher, H. | |
| dc.contributor.author | Abdullah, I. | |
| dc.contributor.author | Rahman, N.A. | |
| dc.date.accessioned | 2018-03-06T03:49:08Z | - |
| dc.date.available | 2018-03-06T03:49:08Z | - |
| dc.date.issued | 2016 | |
| dc.identifier.uri | http://dspace.uniten.edu.my/jspui/handle/123456789/9726 | - |
| dc.description.abstract | Aim: In present study, the anti-inflammatory activities of a new series of benzimidazole derivatives were studied, investigating their inhibition of secretory phospholipase A2, lipoxygenase, COXs and lipopolysaccharide-induced secretion of TNF-α and IL-6 in mouse RAW264.7 macrophages. Results: Synthesized compounds effectively inhibited proinflammatory enzymes and cytokines. Conclusion: A strong inhibition of secretory phospholipases A2 was exhibited by benzimidazole derivatives with trifluoromethyl and methoxy substitutions at position 4 of attached phenyl, whereas compound 8 containing pyridine ring substituted with amino group showed very potent 5-lipoxygenase inhibition. Molecular docking experiments were carried out to elucidate the molecular basis of the observed inhibitory activities. © 2016 Future Science Ltd. | |
| dc.title | Anti-inflammatory trends of new benzimidazole derivatives | |
| item.fulltext | No Fulltext | - |
| item.grantfulltext | none | - |
| crisitem.author.dept | Universiti Tenaga Nasional | - |
| Appears in Collections: | COE Scholarly Publication | |
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